基于MCT的生酮饮食治疗乳腺癌的可行性
2021-8-4 来源:本站原创 浏览次数:次北京白癜风的有效治疗方法 http://m.39.net/pf/bdfyy/bdfal/
概述:
癌细胞高度依赖糖酵解代谢,其特征为葡萄糖摄取和利用增加。有人认为,糖酵解的增加有助于癌细胞的生长,这引起了人们日益浓厚的兴趣,将基于代谢的饮食改变作为一种潜在的新的癌症治疗手段。在这项随机对照试验中,乳腺癌患者在接受90天化疗的同时,给予高脂肪低葡萄糖的生酮饮食(KD)。试验结果表明,KD治疗乳腺癌具有安全性、可耐受和有效性,无明显副作用。KD组的总生存率也高于对照组。提示化疗联合KD治疗乳腺癌是一种有效的方法。
期刊:
NutritionandCancer
DOI:
10./..
译者:
琴晓
原文摘要Feasibility,Safety,andBeneficialEffectsofMCT-BasedKetogenicDietforBreastCancerTreatment:ARandomizedControlledTrialStudy
Journal:
NutritionandCancer
DOI:
10./..
Summary:
Cancercellsarehighlydependentonglycolyticmetabolism,whichischaracterisedbyanenhanceduptakeandutilisationofglucose.Itisthoughtthatelevatedglycolysissupportsincreasedcancercellgrowth,andthishassparkedagrowinginterestintargetingmetabolic-baseddietarymodificationsasapotentialnewcancertreatment.Inthisrandomisedcontrolledtrial,patientswithbreastcancerweregivenaketogenicdiet(KD),whichishighinfatandlowinglucose,atthesametimeasreceivingchemotherapyoveraperiodof90days.Theresultsdemonstratedsafety,tolerabilityandbeneficialeffectsofaKDforthetreatmentofbreastcancer,withnosubstantialsideeffects.OverallsurvivalwasalsohigherintheKDgroup